AN UNBIASED VIEW OF PKRRATING

The activated enzyme then phosphorylates its important substrate, the translational initiation component eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to your conserved relatives of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in response to various stimuli12, triggering the integrated